Lipid transfer proteins (LTPs) are crucial players in nonvesicular lipid trafficking. LTPs sharing a lipocalin lipid transfer domain (lipocalin-like proteins) have a wide range of biological functions, such as regulating immune responses and cell proliferation, differentiation, and death as well as participating in the pathogenesis of inflammatory, metabolic, and neurological disorders and cancer. Therefore, the development of small-molecule inhibitors targeting these LTPs is important and has potential clinical applications. Herein, we summarize the structure and function of lipocalin-like proteins, mainly including retinol-binding proteins, lipocalins, and fatty acid-binding proteins and discuss the recent advances on small-molecule inhibitors for these protein families and their applications in disease treatment. The findings of our Perspective can provide guidance for the development of inhibitors of these LTPs and highlight the challenges that might be faced during the procedures.

中文翻译：

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类脂质运载蛋白小分子抑制剂的研究进展

脂质转移蛋白（LTP）是非囊泡脂质运输的关键参与者。共享脂质运载蛋白脂质转移结构域（脂质运载蛋白样蛋白）的 LTP 具有广泛的生物学功能，例如调节免疫反应和细胞增殖、分化和死亡，以及参与炎症、代谢和神经系统疾病和疾病的发病机制。癌症。因此，开发针对这些LTP的小分子抑制剂非常重要并且具有潜在的临床应用。本文综述了脂质运载蛋白样蛋白的结构和功能，主要包括视黄醇结合蛋白、脂质运载蛋白和脂肪酸结合蛋白，并讨论了这些蛋白家族小分子抑制剂的最新进展及其在疾病治疗中的应用。我们的观点的研究结果可以为这些 LTP 抑制剂的开发提供指导，并强调手术过程中可能面临的挑战。