Early-onset colorectal cancer (EO-CRC) incidence and prevalence trends in the rise in high income countries, such as the Gulf Cooperation Council (GCC) countries. The study aimed to offer an up-to-date assessment of the overall burden of CRC, and EO-CRC in GCC countries and project its incidence and mortality in 2030. The prevalence, incidence, mortality, years of life lived with disability (YLDs), and disability-adjusted life years (DALYs) of CRC were obtained from the Global Burden of Disease (GBD) Study 2019. The incidence and mortality of CRC, and EO-CRC up to 2030 were predicted. All GCC countries showed a higher annual average percentage changes (AAPC) AAPC incidence rate for EO-CRC compared to CRC. In Saudi Arabia the number of CRC cases has increased from 1990 1484.57; (95 % UI 1987.98,1083.86) 11.4-fold-increase to 16991.83; (95 % UI 21754.79,12892.12) in 2019. In 2030, the total incidence cases of CRC for the six Gulf countries are expected to reach 13,339 thousand, primarily driven by Saudi Arabia with 7,910.19 cases. In 2030, the CRC mortality rate is projected to be 7,647 cases, with nearly 57 % of CRC mortality cases anticipated in Saudi Arabia. This study sheds light on the alarming rise in CRC and EO-CRC across Gulf countries from 1990 to 2019, emphasizing Saudi Arabia's significant burden. It projects a concerning increase in CRC incidence and mortality by 2030, primarily in Saudi Arabia, and highlights the need for immediate public health interventions.

中文翻译：

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1990年至2019年海湾合作委员会国家总结直肠癌和早发结直肠癌的疾病负担和预测

早发性结直肠癌（EO-CRC）发病率和患病率在高收入国家呈上升趋势，例如海湾合作委员会（GCC）国家。该研究旨在对海湾合作委员会国家的 CRC 和 EO-CRC 总体负担进行最新评估，并预测 2030 年的发病率和死亡率。患病率、发病率、死亡率、残疾寿命 (YLD) ）和 CRC 的伤残调整生命年（DALY）来自 2019 年全球疾病负担（GBD）研究。预测了截至 2030 年的 CRC 和 EO-CRC 的发病率和死亡率。与 CRC 相比，所有海湾合作委员会国家 EO-CRC 的年平均百分比变化 (AAPC) AAPC 发病率更高。在沙特阿拉伯，结直肠癌病例数比 1990 年增加了 1,484.57 例； （95% UI 1987.98,1083.86）增加11.4倍至16991.83； (95 % UI 21754.79,12892.12) 2019 年。到 2030 年，六个海湾国家的 CRC 总发病病例预计将达到 13,339 万例，主要由沙特阿拉伯推动，病例数为 7,910.19 例。到 2030 年，结直肠癌死亡率预计将达到 7,647 例，其中沙特阿拉伯将占结直肠癌死亡率的近 57%。这项研究揭示了 1990 年至 2019 年间海湾国家 CRC 和 EO-CRC 的惊人增长，强调了沙特阿拉伯的重大负担。该报告预计，到 2030 年，结直肠癌的发病率和死亡率将出现令人担忧的上升，主要是在沙特阿拉伯，并强调需要立即采取公共卫生干预措施。