Astrocytes play an important role in neuroinflammation by producing proinflammatory molecules. In response to various stressful stimuli, astrocytes can become senescent or reactive, both are present in age-associated cognitive impairment and other neurodegenerative diseases, and contribute to neuroinflammation. However, there are no studies that compare the cytokines secreted by these types of astrocytes in the brain during aging. Hence, we aimed to broaden the picture of the secretory profiles and to differentiate the variability between them. Therefore, a systematic review was conducted following the guidelines of the “Reporting Items for Systematic Review and Meta-Analyses”. Only three studies that met the inclusion terms evaluated age-related cytokine secretion, however, no evaluation of senescence or gliosis was performed. Consequently, to increase the spectrum of the review, studies where those phenotypes were induced and cytokines determined were included. Although some cytokines were common for gliosis and senescence, some interesting differences were also found. The dissimilarities in cytokines secretion between these phenotypes could be studied in the future as potential markers.

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衰老和反应性星形胶质细胞的细胞因子分析：系统评价

星形胶质细胞通过产生促炎分子在神经炎症中发挥重要作用。为了应对各种压力刺激，星形胶质细胞可能会衰老或反应性，这两种情况都存在于与年龄相关的认知障碍和其他神经退行性疾病中，并导致神经炎症。然而，目前还没有研究比较衰老过程中大脑中这些类型的星形胶质细胞分泌的细胞因子。因此，我们的目的是拓宽分泌概况的范围并区分它们之间的变异性。因此，按照“系统评价和荟萃分析的报告项目”的指南进行了系统评价。只有三项符合纳入条件的研究评估了与年龄相关的细胞因子分泌，但是没有对衰老或神经胶质增生进行评估。因此，为了扩大综述的范围，包括诱导这些表型和测定细胞因子的研究。尽管一些细胞因子在神经胶质增生和衰老中很常见，但也发现了一些有趣的差异。这些表型之间细胞因子分泌的差异可以作为潜在的标记在未来进行研究。