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Self-sustaining inflammatory cycle causes memory impairment in neuropsychiatric lupus
Nature Immunology ( IF 30.5 ) Pub Date : 2024-03-22 , DOI: 10.1038/s41590-024-01786-0


Autoantibodies that develop in systemic lupus erythematosus (SLE) can cause long-term cognitive impairment that remains even after the systemic disease becomes quiescent. This study attributes the persistent cognitive symptoms of SLE to a self-sustaining neuroinflammatory process that continues indefinitely unless disrupted — which can be done using medications approved by the US Food and Drug Administration.

中文翻译:

自我维持的炎症循环导致神经精神狼疮的记忆障碍

系统性红斑狼疮 (SLE) 中产生的自身抗体可导致长期认知障碍,即使在系统性疾病静止后,这种障碍仍然存在。这项研究将系统性红斑狼疮的持续认知症状归因于一种自我维持的神经炎症过程,除非受到干扰,否则该过程会无限期地持续下去——这可以使用美国食品和药物管理局批准的药物来完成。
更新日期:2024-03-24
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