This work describes the asymmetric synthesis of an aromatic analogue of lipoxin B₄ containing a conformationally rigid and potentially more metabolically resistant bicyclo[1.1.1]pentane (BCP) ring incorporated into the upper alkyl chain. This was achieved via the design of a key BCP-containing fragment that could be used as a common intermediate in the synthesis of the target analogue as well as other heteroaromatic congeners.

中文翻译：

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含双环[1.1.1]戊烷的芳香族脂氧素 B4 类似物和杂芳香族同系物的合成

_{这项工作描述了脂氧素 B 4}的芳香族类似物的不对称合成，该类似物包含构象刚性且可能更具代谢耐受性的双环[1.1.1]戊烷（BCP）环并入上部烷基链中。这是通过设计一个包含 BCP 的关键片段来实现的，该片段可用作合成目标类似物以及其他杂芳族同系物的通用中间体。