An iron-catalyzed ring-opening azidation of cyclobutanols through CC bond cleavage is disclosed for the first time. A range of tertiary cyclobutanols are tolerated providing γ-carbonyl-containing secondary alkyl azides. The method provides a straightforward approach for introducing azide group into aliphatic chain of organic molecules. A plausible mechanism involving radical-mediated sequential CC bond cleavage and C−N bond formation is proposed.

中文翻译：

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铁催化 C[sbnd]C 键断裂叠氮化环丁醇

首次公开了铁催化环丁醇通过CC键断裂的开环叠氮化反应。可以耐受一系列叔环丁醇，提供含γ-羰基的仲烷基叠氮化物。该方法提供了一种将叠氮基引入有机分子的脂肪链中的简单方法。提出了一种涉及自由基介导的连续 CC 键断裂和 CN 键形成的合理机制。