Eomesodermin-expressing (Eomes⁺) T-helper (Th) cells show cytotoxic characteristics in secondary progressive multiple sclerosis. We found that Eomes⁺ Th cell frequency was increased in the peripheral blood of amyotrophic lateral sclerosis and Alzheimer's disease patients. Furthermore, granzyme B production by Th cells from such patients was high compared with controls. A high frequency of Eomes⁺ Th cells was observed in the initial (acutely progressive) stage of amyotrophic lateral sclerosis, and a positive correlation between Eomes⁺ Th cell frequency and cognitive decline was observed in Alzheimer's disease patients. Therefore, Eomes⁺ Th cells may be involved in the pathology of amyotrophic lateral sclerosis and Alzheimer's disease. ANN NEUROL 2024;95:1093–1098

中文翻译：

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表达 Eomesodermin 的 T 辅助细胞在神经退行性疾病中的致病潜力


表达脱中胚蛋白 (Eomes ⁺ ) 的 T 辅助细胞 (Th) 在继发性进行性多发性硬化症中表现出细胞毒性特征。我们发现肌萎缩侧索硬化症和阿尔茨海默病患者的外周血中 Eomes ⁺ Th 细胞频率增加。此外，与对照组相比，此类患者的 Th 细胞产生的颗粒酶 B 较高。在肌萎缩侧索硬化症的初始（急性进展）阶段观察到Eomes ⁺ Th细胞频率较高，并且在阿尔茨海默病患者中观察到Eomes ⁺ Th细胞频率与认知能力下降呈正相关。因此，Eomes ⁺ Th细胞可能参与肌萎缩侧索硬化症和阿尔茨海默病的病理过程。安神经学 2024 年；95：1093–1098