Newborn hyperbilirubinemia during the first two weeks of life is one of most common problems requiring management decisions by a pediatrician. However, high bilirubin levels in the circulation have been associated with neurologic injury under a variety of conditions encountered in the newborn infant, such as hemolysis. The risk for developing dangerous hyperbilirubinemia is multifactorial and is determined by a complex set of factors related to a newborn infant’s genetic capacities as well as intra- and extrauterine exposures. To this end, a precision health approach based on the integration of prenatal genetic and postnatal diagnostic measures might improve the management of neonatal hyperbilirubinemia.

新生儿生命前两周的高胆红素血症是需要儿科医生做出处理决定的最常见问题之一。然而，循环中的高胆红素水平与新生儿遇到的各种情况下的神经损伤有关，例如溶血。发生危险的高胆红素血症的风险是多因素的，由与新生儿的遗传能力以及宫内和宫外暴露相关的一系列复杂因素决定。为此，基于产前遗传和产后诊断措施相结合的精准健康方法可能会改善新生儿高胆红素血症的管理。