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Microbial metabolite enhances immunotherapy efficacy by modulating T cell stemness in pan-cancer
Cell ( IF 64.5 ) Pub Date : 2024-03-14 , DOI: 10.1016/j.cell.2024.02.022 Dingjiacheng Jia , Qiwen Wang , Yadong Qi , Yao Jiang , Jiamin He , Yifeng Lin , Yong Sun , Jilei Xu , Wenwen Chen , Lina Fan , Ruochen Yan , Wang Zhang , Guohong Ren , Chaochao Xu , Qiwei Ge , Lan Wang , Wei Liu , Fei Xu , Pin Wu , Yuhao Wang , Shujie Chen , Liangjing Wang
Cell ( IF 64.5 ) Pub Date : 2024-03-14 , DOI: 10.1016/j.cell.2024.02.022 Dingjiacheng Jia , Qiwen Wang , Yadong Qi , Yao Jiang , Jiamin He , Yifeng Lin , Yong Sun , Jilei Xu , Wenwen Chen , Lina Fan , Ruochen Yan , Wang Zhang , Guohong Ren , Chaochao Xu , Qiwei Ge , Lan Wang , Wei Liu , Fei Xu , Pin Wu , Yuhao Wang , Shujie Chen , Liangjing Wang
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and collaborate to produce indole-3-propionic acid, which modulates CD8 T cell stemness by increasing H3K27 acetylation at the super-enhancer, thereby enhancing the anti-tumor effect of immune checkpoint blockade in pan-cancer.
中文翻译：
微生物代谢物通过调节泛癌中的 T 细胞干性来增强免疫治疗效果
并合作生产吲哚-3-丙酸，通过增加超级增强子处的H3K27乙酰化来调节CD8 T细胞干性，从而增强免疫检查点阻断在泛癌中的抗肿瘤作用。
更新日期：2024-03-14
中文翻译：
微生物代谢物通过调节泛癌中的 T 细胞干性来增强免疫治疗效果
并合作生产吲哚-3-丙酸，通过增加超级增强子处的H3K27乙酰化来调节CD8 T细胞干性，从而增强免疫检查点阻断在泛癌中的抗肿瘤作用。
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