The relationships between sleep duration and aging-associated diseases are intricate. Leukocyte telomere length (LTL) is a biomarker of aging, while the association of sleep duration and LTL is unclear. The 310,091 study participants from UK Biobank were enrolled in this cross-sectional study. Restricted cubic splines (RCS) analysis was firstly performed to assess the nonlinear relationship between sleep duration and LTL. Sleep duration was then categorized into three groups: <7 h (short sleep duration), 7–8 h (reference group), and >8 h (long sleep duration) and multiple linear regression was applied to analyze the association of short sleep and long sleep duration with LTL. We further performed subgroup analyses stratified by sex, age, chronotype and snoring. RCS showed an inverted J-shaped relationship between sleep duration and LTL. Compared with the reference group, the inverse association of long sleep duration and LTL was statistically significant in fully-adjusted model ( = 0.001). Subgroup analyses showed that this association was more apparent in people over 50 years (51–60 y: = 0.002; >60 y: = 0.005), in men ( = 0.022), and in people preferred evening chronotype ( = 0.001). Compared with participants sleeping 7–8 h, those sleep longer than 8 h had shorter LTL in middle-aged and young-old adults. The negative association between long sleep duration and LTL was more apparent in older people, in men, and in people preferred evening chronotype.

中文翻译：

---

中青年人睡眠时间与白细胞端粒长度的关系：英国生物银行的横断面研究

睡眠时间与衰老相关疾病之间的关系错综复杂。白细胞端粒长度 (LTL) 是衰老的生物标志物，而睡眠持续时间和 LTL 之间的关系尚不清楚。来自英国生物银行的 310,091 名研究参与者参加了这项横断面研究。首先进行限制三次样条 (RCS) 分析来评估睡眠持续时间和 LTL 之间的非线性关系。然后将睡眠时间分为三组：<7 小时（短睡眠时间）、7-8 小时（参考组）和 >8 小时（长睡眠时间），并应用多元线性回归来分析短睡眠与睡眠时间之间的关联。 LTL 睡眠时间长。我们进一步进行了按性别、年龄、睡眠时间类型和打鼾分层的亚组分析。 RCS 显示睡眠持续时间和 LTL 之间呈倒 J 形关系。与参考组相比，在完全调整的模型中，长睡眠时间与 LTL 的负相关具有统计学意义（= 0.001）。亚组分析表明，这种关联在 50 岁以上人群（51-60 岁：= 0.002；>60 岁：= 0.005）、男性（= 0.022）和偏好夜间睡眠类型的人群（= 0.001）中更为明显。与睡眠7-8小时的参与者相比，睡眠时间超过8小时的中青年人的LTL较短。长睡眠时间与 LTL 之间的负相关性在老年人、男性和偏好夜间睡眠模式的人中更为明显。