A wide range of N-CF₃ imidoyl chlorides were synthesized for the first time via the N-trifluoromethylation of nitriles in DCM by using AlCl₃-activated PhICF₃Cl as the CF₃ source. The reactions of them with N-/O-/S-nucleophiles, as well as with 1,3-dipoles, were carried out to efficiently deliver N-CF₃ amidines/imidates/thioimidates and N-CF₃ azoles, demonstrating that they are a class of scalable NCF₃-containing synthons in the synthesis of N-CF₃ compounds.

中文翻译：

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N-CF3 亚氨酰氯：用于构建 N-CF3 化合物的可扩展 N-CF3 氮前体

_{以AlCl 3}活化的PhICF ₃ Cl为CF _{3源，通过DCM中腈的}N-三氟甲基化反应，首次合成了多种N -CF ₃亚氨基氯化物。它们与N- /O-/S-亲核试剂以及与1,3-偶极子的反应可有效传递N -CF ₃脒/亚氨酸酯/硫代亚氨酸酯和N -CF ₃唑，证明它们是一类在N -CF ₃化合物合成中可扩展的含NCF ₃合成子。