An iodoarene-driven electroreductive remote C(sp³)–H arylation of unsymmetrical 1-(o-iodoaryl)alkyl ethers with cyanoarenes for the site selective synthesis of α-(hetero)aryl ethers is developed. With the introduction of cyanoarenes as both aryl sources and electron transfer mediators, this method includes an iodoarene-driven strategy to enable the regiocontrollable formation of two new bonds, one C(sp²)–H bond, and one C(sp²)–C(sp³) bond, in a single reaction step through the sequence of halogen atom transfer (XAT), hydrogen atom transfer (HAT), radical–radical coupling, and decyanation.

中文翻译：

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使用氰基芳烃对脂肪族醚进行电还原远程苯甲基 C(sp3)–H 芳基化以合成 α-(杂)芳基醚

开发了一种碘芳烃驱动的不对称1-(邻碘芳基)烷基醚与氰基芳烃的远程电还原C(sp ³ )–H芳基化反应，用于α-(杂)芳基醚的位点选择性合成。通过引入氰基芳烃作为芳基源和电子转移介体，该方法包括一种碘芳烃驱动策略，能够区域可控地形成两个新键，一个 C(sp ² )–H 键和一个 C(sp ² )– C(sp ³ ) 键，在一个反应​​步骤中通过卤素原子转移 (XAT)、氢原子转移 (HAT)、自由基-自由基偶联和脱氰化的顺序。