Autoimmune responses have been suggested to involvement in patients with Behcet’s syndrome (BS). There has been growing attention towards the roles of cutaneous lymphocyte antigen (CLA)+ regular T cells (Tregs) in autoimmune diseases. The role of CLA+ Tregs in BS is still uncertain. This study aims to clarify the impact of CLA+ Tregs on BS. We collected peripheral blood from a total of 107 patients with BS and 114 healthy controls (HCs). The number of CLA+ Tregs, natural killer (NK) cells, B cells, and several subtypes of CD4+ T cells were detected using flow cytometry and compared between patients and HCs. The absolute number and proportion of CLA+ Tregs among CD4+ T lymphocytes and CD4+ Tregs were lower in patients with BS than in HCs. CLA+ Tregs were positively related with NK cells (r = 0.500, P < 0.001) and B cells (r = 0.470, P < 0.001) and negatively related with effector T cells (r=-0.402, P < 0.001) in patients with BS. Patients with BS and arterial aneurysms had CLA+ Treg cell deficiency. A decreased proportion of CLA+ Tregs was associated with arterial aneurysms in patients with BS. The proportion of CLA+ Tregs in patients with BS increased with corticosteroids and immunosuppressants. CLA+ Tregs decrease in association with arterial aneurysm in patients with BS. CLA+ Tregs may be a predictor of response to BS treatment.

中文翻译：

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外周 CLA+ Tregs 的缺乏与白塞氏综合征的临床相关性

白塞氏综合征 (BS) 患者可能存在自身免疫反应。皮肤淋巴细胞抗原 (CLA) + 常规 T 细胞 (Treg) 在自身免疫性疾病中的作用越来越受到关注。 CLA+ Tregs 在 BS 中的作用仍不确定。本研究旨在阐明 CLA+ Tregs 对 BS 的影响。我们总共收集了 107 名 BS 患者和 114 名健康对照 (HC) 的外周血。使用流式细胞术检测 CLA+ Tregs、自然杀伤 (NK) 细胞、B 细胞和 CD4+ T 细胞的几种亚型的数量，并在患者和 HC 之间进行比较。 BS患者的CD4+ T淋巴细胞和CD4+ Tregs中CLA+ Tregs的绝对数量和比例低于HC患者。 BS 患者中 CLA+ Tregs 与 NK 细胞（r = 0.500，P < 0.001）和 B 细胞（r = 0.470，P < 0.001）呈正相关，与效应 T 细胞呈负相关（r=-0.402，P < 0.001） 。患有 BS 和动脉瘤的患者存在 CLA+ Treg 细胞缺陷。 CLA+ Tregs 比例下降与 BS 患者的动脉瘤相关。 BS 患者中 CLA+ Tregs 的比例随着皮质类固醇和免疫抑制剂的使用而增加。 BS 患者的 CLA+ Tregs 减少与动脉瘤相关。 CLA+ Tregs 可能是 BS 治疗反应的预测因子。