Co-inhibition of TGF-β and PD-L1 pathways in a metastatic colorectal cancer mouse model triggers interferon responses, innate cells and T cells, alongside metabolic changes and tumor resistance,OncoImmunology

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Co-inhibition of TGF-β and PD-L1 pathways in a metastatic colorectal cancer mouse model triggers interferon responses, innate cells and T cells, alongside metabolic changes and tumor resistance
OncoImmunology ( IF 7.2 ) Pub Date : 2024-03-20 , DOI: 10.1080/2162402x.2024.2330194
Reshmi Nair ₁ , Tamsin R. M. Lannagan ₂ , Rene Jackstadt ₂ , Anna Andrusaite ₁ , John Cole ₁ , Caitlin Boyne ₁ , Robert J. B. Nibbs ₁ , Owen J. Sansom _{2,

3} , Simon Milling ₁

Affiliation

Colorectal cancer (CRC) is the third most prevalent cancer worldwide with a high mortality rate (20–30%), especially due to metastasis to adjacent organs. Clinical responses to chemotherapy, radiat...

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