Antiseizure medications are commonly used in persons of childbearing potential for multiple indications (e.g., epilepsy, pain, and psychiatric disorders). All antiseizure medications are potential teratogens that could cause congenital malformations and cognitive or behavioral impairments.¹ However, these effects vary markedly across antiseizure medications. For example, fetal exposure to valproate has been repeatedly associated with neuropsychological impairments, whereas many studies have shown no such association with fetal exposure to lamotrigine.² A recent large, population-based study involving five Nordic countries showed an association between fetal exposure to topiramate and the risk of autism spectrum disorder.³ Among children born to mothers with epilepsy, . . .

抗癫痫药物通常用于具有多种适应症（例如癫痫、疼痛和精神疾病）的育龄人群。所有抗癫痫药物都是潜在的致畸剂，可能导致先天性畸形和认知或行为障碍。¹然而，不同抗癫痫药物的这些作用存在显着差异。例如，胎儿接触丙戊酸一再与神经心理损伤相关，而许多研究表明胎儿接触拉莫三嗪没有这种关联。²最近一项涉及五个北欧国家的大型人口研究表明，胎儿接触托吡酯与患自闭症谱系障碍的风险之间存在关联。³在患有癫痫的母亲所生的孩子中，. 。 。