Hyperatins A–D (–), four previously undescribed polycyclic polyprenylated acylphloroglucinols, were isolated from L. (St. John's wort). Compound possessed a unique octahydroindeno[1,7a-]oxirene ring system with a rare 2,7-dioxabicyclo[2.2.1]heptane fragment. Compounds – had an uncommon decahydrospiro[furan-3,7′-indeno[7,1-]furan] ring system. Their structures were established by spectroscopic analyses and X-ray crystallography. Plausible biosynthetic pathways of – were also proposed. Compounds and exerted promising hypoglycemic activity by inhibiting glycogen synthase kinase 3 expression in liver cells.

中文翻译：

---

Hyperatins A–D，来自贯叶金丝桃的高度氧化的多环聚异戊二烯酰基间苯三酚，在肝细胞中具有降血糖潜力

Hyperatins A–D (–) 是从圣约翰草 (St. John's wort) 中分离出来的四种先前未描述的多环聚异戊二烯酰基间苯三酚。化合物具有独特的八氢茚并[1,7a-]氧杂环系统和罕见的2,7-二氧杂双环[2.2.1]庚烷片段。化合物 – 具有罕见的十氢螺[呋喃-3,7'-茚并[7,1-]呋喃]环系统。它们的结构是通过光谱分析和X射线晶体学确定的。还提出了合理的生物合成途径。化合物通过抑制肝细胞中糖原合成酶激酶 3 的表达而发挥出有希望的降血糖活性。