For the first time, the successful synthesis of 4,4-bis(5-methylthiophen-2-yl)pentanoic acid (bisthiophenic acid-methyl; BTA-M) and its alkyl esters (BTAE-M) from levulinic acid (LA) and its esters with 2-Methylthiophene (2-Met) has been achieved, utilizing solid acid catalysts (Amberlyst-15 and Indion-190). Notably, Indion-190, a cost-effective catalyst, demonstrated the formation of BTA-M and bisthiophenic methyl ester-methyl (BTME-M) with 96–98% selectivities and 99% conversion of LA and methyl levulinate under optimized, solvent-free reaction conditions. The recyclability of Indion-190 has been showcased, maintaining good recyclability for the preparation of BTA-M and BTME-M over three reaction cycles, with a slight decrease in the conversion of reactants.

中文翻译：

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固体酸催化剂从生物质基功能分子制备4,4-双(5-甲基噻吩-2-基)戊酸

首次以乙酰丙酸（LA）为原料成功合成4,4-双（5-甲基噻吩-2-基）戊酸（双噻吩酸甲酯；BTA-M）及其烷基酯（BTAE-M）利用固体酸催化剂（Amberlyst-15 和 Indion-190）制备了其与 2-甲基噻吩 (2-Met) 的酯。值得注意的是，Indion-190 是一种经济高效的催化剂，在优化的溶剂-溶剂条件下，BTA-M 和双噻吩甲酯甲基 (BTME-M) 的形成选择性为 96-98%，LA 和乙酰丙酸甲酯的转化率为 99%。自由反应条件。 Indion-190的可回收性得到了展示，在三个反应循环中，BTA-M和BTME-M的制备保持了良好的可回收性，反应物的转化率略有下降。