Transdermal drug delivery holds great promise for enhancing therapeutic outcomes and patient compliance, and bioinspired 4D microneedles represent a cutting-edge approach in this field. This review provides a concise overview on the current progress and future prospects in the development of bioinspired 4D transdermal microneedles for drug delivery. Bioinspired 4D microneedles combine the principles of biomimicry and advanced materials science to create dynamic, responsive drug delivery systems. They are designed to overcome the limitations of conventional transdermal patches by offering enhanced control over drug release, improved patient comfort, and the ability to adapt to the dynamic properties of the skin. In this article, we discuss various fabrication techniques, materials, and designs are discussed that have been explored to create these innovative microneedles. This article explores various fabrication techniques, materials and designs of innovative microneedles. Current research in this field has demonstrated that bioinspired 4D microneedles enables precise and controlled drug administration for a wide range of therapeutic applications. These microneedles have shown potential in delivering both small molecule drugs and biologics, making them versatile tools in the pharmaceutical industry. Ongoing research efforts focus on improving biocompatibility, scalability, and commercial viability. The integration with smart technologies such as sensors and feedback control systems enable personalized and responsive delivery of drug. Bioinspired 4D transdermal microneedles represent a transformative approach to drug delivery. They offer precise, patient-friendly, and adaptable solutions for delivering a wide range of therapeutics. With continued research and development, Bioinspired 4D microneedles have the potential to revolutionize the way of drug administration, ultimately improving healthcare of the patient.

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仿生 4D 透皮微针彻底改变药物输送：进展和未来前景

透皮给药在提高治疗效果和患者依从性方面具有广阔的前景，而仿生 4D 微针代表了该领域的前沿方法。本综述简要概述了用于药物输送的仿生 4D 透皮微针开发的当前进展和未来前景。仿生 4D 微针结合了仿生学和先进材料科学的原理，创造出动态、响应性的药物输送系统。它们旨在通过增强对药物释放的控制、提高患者舒适度以及适应皮肤动态特性的能力来克服传统透皮贴剂的局限性。在本文中，我们讨论了为创造这些创新微针而探索的各种制造技术、材料和设计。本文探讨了创新微针的各种制造技术、材料和设计。该领域目前的研究表明，仿生 4D 微针能够为广泛的治疗应用提供精确和受控的药物给药。这些微针在输送小分子药物和生物制剂方面显示出潜力，使其成为制药行业的多功能工具。正在进行的研究工作重点是提高生物相容性、可扩展性和商业可行性。与传感器和反馈控制系统等智能技术的集成可实现个性化和响应式的药物输送。仿生 4D 透皮微针代表了一种变革性的药物输送方法。他们提供精确、患者友好且适应性强的解决方案，以提供广泛的治疗。通过不断的研究和开发，Bioinspired 4D 微针有可能彻底改变给药方式，最终改善患者的医疗保健。