The study of salivary microelements and their neurophysiological and behavioral correlates in patients with obsessive-compulsive disorder (OCD) is a pressing issue in modern psychiatry, which, however, lacks adequate research at this time. In this study, we tested the dynamics of behavioral parameters, resting-state electroencephalogram (EEG), and salivary iron, copper, manganese, magnesium, and zinc in 30 healthy volunteers and 30 individuals with OCD before and after an emotional antisaccade task. The eye-movement data served as a measure of behavioral performance. Our research revealed consistently higher manganese concentrations in the OCD group compared to healthy volunteers associated with a higher EEG ratio of amplitude transformation and symptom severity. The dynamics of salivary microelements and resting-state EEG, possibly influenced by cognitive and emotional load during the anticsaccade task, differed between groups. In healthy volunteers, there was a decrease in salivary iron level with an increase in high-frequency power spectral density of EEG. The OCD group showed a decrease in salivary copper with an increased Hjorth mobility of EEG.

中文翻译：

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强迫症患者静息态脑电图和唾液微量元素的动态

对强迫症（OCD）患者唾液微量元素及其神经生理学和行为相关性的研究是现代精神病学的一个紧迫问题，但目前缺乏足够的研究。在这项研究中，我们测试了 30 名健康志愿者和 30 名强迫症患者在情绪抗眼跳任务前后的行为参数、静息态脑电图 (EEG) 和唾液铁、铜、锰、镁和锌的动态变化。眼动数据可作为行为表现的衡量标准。我们的研究表明，与健康志愿者相比，强迫症组的锰浓度始终较高，这与较高的脑电图振幅变换比率和症状严重程度相关。唾液微量元素和静息态脑电图的动态可能受到反跳频任务期间认知和情绪负荷的影响，在各组之间存在差异。在健康志愿者中，随着脑电图高频功率谱密度的增加，唾液铁水平下降。强迫症组表现出唾液铜减少，脑电图 Hjorth 迁移率增加。