INTRODUCTIONPeople with Down syndrome (DS) have high risk of developing Alzheimer's disease (AD). This study examined mean ages of AD diagnosis and associations with co‐occurring conditions among adults with DS from five European countries.METHODSData from 1335 people with DS from the Horizon 21 European DS Consortium were used for the analysis.RESULTSMean ages of AD diagnosis ranged between 51.4 (SD 7.0) years (United Kingdom) and 55.6 (SD 6.8) years (France). Sleep‐related and mental health problems were associated with earlier age of AD diagnosis. The higher number of co‐occurring conditions the more likely the person with DS is diagnosed with AD at an earlier age.DISCUSSIONMean age of AD diagnosis in DS was relatively consistent across countries. However, co‐occurring conditions varied and impacted on age of diagnosis, suggesting that improvements can be made in diagnosing and managing these conditions to delay onset of AD in DS.Highlights Mean age of AD diagnosis was relatively consistent between countries Sleep problems and mental health problems were associated with earlier age of AD diagnosis APOE ε4 carriers were diagnosed with AD at an earlier age compared to non‐carriers Number of co‐occurring conditions was associated with earlier age of AD diagnosis No differences between level of intellectual disability and mean age of AD diagnosis

中文翻译：

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唐氏综合症患者阿尔茨海默病诊断年龄及相关因素：Horizo​​n 21 欧洲唐氏综合症联盟的结果

简介 患有唐氏综合症 (DS) 的人患阿尔茨海默病 (AD) 的风险很高。本研究调查了来自五个欧洲国家的 DS 成人的 AD 诊断平均年龄以及与并发疾病的关联。方法使用来自 Horizo​​n 21 欧洲 DS 联盟的 1335 名 DS 患者的数据进行分析。结果 AD 诊断的平均年龄介于51.4 (SD 7.0) 年（英国）和 55.6 (SD 6.8) 年（法国）。睡眠相关和心理健康问题与 AD 诊断年龄较早有关。并发疾病的数量越多，DS 患者在较早的年龄被诊断出 AD 的可能性就越大。讨论 DS 中 AD 诊断的平均年龄在各个国家之间相对一致。然而，同时发生的病症各不相同，并影响诊断年龄，这表明可以在诊断和管理这些病症方面做出改进，以延迟 DS 中 AD 的发病。 各国之间 AD 诊断的平均年龄相对一致 睡眠问题和心理健康问题与 AD 诊断年龄较早有关 与非携带者相比，APOE ε4 携带者被诊断出 AD 的年龄更早 并发疾病的数量与早期 AD 诊断年龄相关 智力障碍水平与 AD 诊断平均年龄之间没有差异