Phosphine-catalyzed chemodivergent reactions of p-QMs have been developed. The direct 1,6-addition of p-QMs with thiols was catalyzed by P(4-FC₆H₄)₃, while P(4-MeC₆H₄)₃ catalyzed the tandem addition/self-aldol condensation reactions of p-QMs with 1,4-dithiane-2,5-diol. Furthermore, one of the products diarylmethyl thioether was shown to have an inhibitory effect on the proliferation of all cancer cell types in the study.

中文翻译：

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膦催化对醌甲基化物与硫醇的 1,6-加成和串联加成/自羟醛缩合反应

已开发出磷化氢催化的p -QM 化学发散反应。 P(4-FC ₆ H ₄ ) ₃催化p -QMs与硫醇的直接1,6-加成反应，而P(4-MeC ₆ H ₄ ) _3催化p -QMs的串联加成/自醛醇缩合反应-具有 1,4-二噻烷-2,5-二醇的 QM。此外，研究显示其中一种产品二芳基甲基硫醚对所有癌细胞类型的增殖都有抑制作用。