Palladium-Catalyzed Dehydrogenative Carbonylative Esterification of Allenoic Acids for the Synthesis of γ-Butyrolactone Derivatives,Organic Letters

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Palladium-Catalyzed Dehydrogenative Carbonylative Esterification of Allenoic Acids for the Synthesis of γ-Butyrolactone Derivatives
Organic Letters ( IF 4.9 ) Pub Date : 2024-03-19 , DOI: 10.1021/acs.orglett.4c00572
Bolin Wang ₁ , Mingzhe Ren ₁ , Nasir Iqbal ₁ , Xin Mu ₁ , Jan-E Bäckvall ₂ , Bin Yang ₁

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A highly efficient dehydrogenative carbonylative esterification of allenoic acids using Pd-catalysis was developed, providing a novel approach to synthesizing esterified γ-butyrolactone derivatives with consistently good to excellent results demonstrated across over 50 examples. Additionally, we used a heterogeneous catalyst known as Pd-AmP-MCF and harnessed biomimetic-aerobic-oxidation conditions to facilitate the practical execution of this reaction. Furthermore, our detailed study of γ-butyrolactone products highlighted their potential in synthesizing bioactive compounds.

中文翻译：

钯催化联烯酸脱氢羰基酯化合成 γ-丁内酯衍生物

开发了一种使用 Pd 催化的联烯酸高效脱氢羰基化酯化方法，提供了一种合成酯化 γ-丁内酯衍生物的新方法，并在 50 多个实例中证明了始终如一的良好至优异的结果。此外，我们使用了一种称为 Pd-AmP-MCF 的多相催化剂，并利用仿生有氧氧化条件来促进该反应的实际执行。此外，我们对 γ-丁内酯产品的详细研究突显了它们在合成生物活性化合物方面的潜力。

更新日期：2024-03-19

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