(+)-Crambescin B decarboxylate was synthesized using a new synthetic strategy, which is nine steps shorter than the previously reported shortest method. We determined its cytotoxicity and protective effects in neuronal HT22 cells with an MTS assay. Cell viability was observed to decrease in a concentration-dependent manner without cell detachment or shrinkage. Additionally, the compound protected glutamate-induced cell death.

中文翻译：

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(+)-Crambescin B 脱羧化物的合成新策略

(+)-Crambescin B 脱羧化物采用新的合成策略合成，比之前报道的最短方法缩短了 9 个步骤。我们通过 MTS 测定确定了其对神经元 HT22 细胞的细胞毒性和保护作用。观察到细胞活力以浓度依赖性方式降低，而没有细胞脱离或收缩。此外，该化合物还可以保护谷氨酸诱导的细胞死亡。