When effective treatments against neurodegenerative diseases become a reality, it will be important to know the age these pathologies begin to develop. We investigated alpha‐synuclein pathology in brain tissue of the Tampere Sudden Death Study—unselected forensic autopsies on individuals living outside hospital institutions in Finland. Of 562 (16–95 years) participants, 42 were positive for Lewy‐related pathology (LRP). The youngest LRP case was aged 54 years, and the frequency of LRP in individuals aged ≥50 years was 9%. This forensic autopsy study indicates LRP starts already in middle age and is more common than expected in the ≥50 years‐of‐age non‐hospitalized population. ANN NEUROL 2024

中文翻译：

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路易相关病理学的积累从中年开始：坦佩雷猝死研究

当针对神经退行性疾病的有效治疗成为现实时，了解这些疾病开始发生的年龄将非常重要。我们调查了坦佩雷猝死研究脑组织中的α-突触核蛋白病理学——对芬兰医院机构外的个体进行未经选择的法医尸检。在 562 名（16-95 岁）参与者中，42 名路易相关病理学 (LRP) 呈阳性。最年轻的LRP病例年龄为54岁，年龄≥50岁个体的LRP发生率为9%。这项法医尸检研究表明，LRP 已开始于中年，并且在 ≥50 岁的非住院人群中比预期更常见。安神经学 2024