The abuse of illicit drugs poses serious threats to the physical and mental health of users, as well as to the overall safety and welfare of society. In this work, we present a newly developed technique for drug detection based on mass spectrometry. This technique combines Leidenfrost desorption with low-temperature arc plasma ionization mass spectrometry. This method is applicable for detecting furanyl fentanyl in complex matrices. Key advantages of this technique include minimal sample fragmentation and high sensitivity for detection. The Leidenfrost desorption plays a pivotal role in this methodology, as it spontaneously concentrates analyte molecules during the gradual evaporation of the solvent. Eventually, these concentrated molecules are redistributed at their highest concentrations, resulting in exceptionally high sensitivity. In the course of our investigation, we achieved a remarkable detection limit of 10 pg mL⁻¹ for furanyl fentanyl in pure water. Moreover, the characteristic ion peaks of furanyl fentanyl can be distinctly identified within complex matrices such as wine, beverages, urine, and lake water. This innovative drug detection technology offers several advantages, including a simple setup, cost-effectiveness, rapid detection, high sensitivity, and minimal sample pretreatment.

中文翻译：

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使用莱顿弗罗斯特解吸辅助低温电弧等离子体电离质谱法快速检测复杂基质中的呋喃基芬太尼

非法药物的滥用对使用者的身心健康以及社会的整体安全和福祉构成严重威胁。在这项工作中，我们提出了一种新开发的基于质谱的药物检测技术。该技术将莱顿弗罗斯特解吸与低温电弧等离子体电离质谱法相结合。该方法适用于检测复杂基质中的呋喃基芬太尼。该技术的主要优点包括样品碎片最少和检测灵敏度高。莱顿弗罗斯特解吸在该方法中起着关键作用，因为它在溶剂逐渐蒸发的过程中自发地浓缩分析物分子。最终，这些浓缩的分子以最高浓度重新分布，从而产生异常高的灵敏度。在我们的研究过程中，我们对纯水中的呋喃基芬太尼实现了 10 pg mL ^-1的显着检测限。此外，可以在酒、饮料、尿液和湖水中等复杂基质中清楚地识别呋喃基芬太尼的特征离子峰。这种创新的药物检测技术具有多种优点，包括设置简单、成本效益高、检测快速、灵敏度高和样品预处理最少。