Objective

In this study, we aimed to evaluate BPA levels in the maternal serum and amniotic fluid of patients diagnosed with NTD. In addition, we wanted to investigate the relationship between neurodevelopmental defects, such as neural tube defects (NTD), and BPA levels.

Study design

This prospective observational study was carried out at Bursa Yüksek İhtisas Training and Research Hospital between April 15, 2021, and April 15, 2022. The study consisted of 92 patients between the ages of 18–45 who had an amniocentesis at 15–22 weeks of gestation. The patients were divided into two groups according to the indications of amniocentesis. Group 1 contained the patients with abnormal maternal serum screening results or cell-free DNA results and abnormal ultrasonography findings (45 patients). Group 2 contained the patients with a pre-diagnosis of NTD (47 patients). The first 5 cc fluids and maternal serum samples taken during the amniocentesis procedure of all patients were delivered to the biochemistry laboratory. The BPA values between groups were compared.

Results

A statistically significant difference was found between the two groups in terms of amniotic fluid BPA levels (36.66 (19.00:82.00) and 39.62 (19.02–73.87)) and maternal blood BPA levels (22.26 (12.60–228) and 47.81 (12.89–228.39)). In cases with NTD, amniotic fluid BPA levels and maternal blood BPA levels were significantly higher than the control group. When AUC values were compared, the AFP numerical value was higher than the amniotic fluid and maternal blood BPA levels.

Conclusion

Plastic, which is indispensable for modern life, may negatively affect fetal development in intrauterine life. The data in this study says that high maternal blood BPA may be associated with NTD.

中文翻译：

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双酚 A 在神经管缺陷的形成中发挥作用吗？

客观的

在这项研究中，我们旨在评估被诊断为 NTD 的患者母体血清和羊水中的 BPA 水平。此外，我们还想研究神经发育缺陷（例如神经管缺陷 (NTD)）与 BPA 水平之间的关系。

学习规划

这项前瞻性观察性研究于 2021 年 4 月 15 日至 2022 年 4 月 15 日在布尔萨尤克塞克伊蒂萨斯培训研究医院进行。该研究由 92 名年龄在 18-45 岁之间的患者组成，他们在出生后 15-22 周接受了羊膜穿刺术。妊娠。根据羊膜穿刺术指征将患者分为两组。第1组包含母体血清筛查结果或游离DNA结果异常以及超声检查结果异常的患者（45名患者）。第 2 组包含预先诊断为 NTD 的患者（47 名患者）。所有患者在羊膜穿刺术过程中采集的前 5 cc 液体和母体血清样本均被送往生化实验室。比较各组间的 BPA 值。

结果

两组羊水 BPA 水平（36.66（19.00:82.00）和 39.62（19.02-73.87））和母血 BPA 水平（22.26（12.60-228）和 47.81（12.89-228.39）之间存在统计学差异。 ））。在 NTD 病例中，羊水 BPA 水平和母血 BPA 水平显着高于对照组。比较AUC值时，AFP数值高于羊水和母血BPA水平。

结论

现代生活不可或缺的塑料可能会对宫内胎儿的发育产生负面影响。这项研究的数据表明，母体血液中高 BPA 可能与 NTD 相关。