Objective To assess health and activities of daily living (ADL) in SARS-CoV-2-positive adults with and without post-COVID-19 condition (PCC) and compare this with negative tested individuals. Furthermore, different PCC case definitions were compared with SARS-CoV-2-negative individuals. Methods All adults tested PCR positive for SARS-CoV-2 at the Public Health Service South Limburg (Netherlands) between June 2020 and November 2021 (n=41 780) and matched PCR negative individuals (2:1, on age, sex, year-quarter test, municipality; n=19 875) were invited by email. Health (five-level EuroQol five-dimension (EQ5D) index and EuroQol visual analogue scale (EQVAS)) and ADL impairment were assessed. PCC classification was done using the WHO case definition and five other common definitions. Results In total, 8409 individuals (6381 SARS-CoV-2 positive; 53±15 years; 57% female; 9 (7–11) months since test) were included. 39.4% of positives had PCC by the WHO case definition (EQVAS: 71±20; EQ5D index: 0.800±0.191; ADL impairment: 30 (10–70)%) and perceived worse health and more ADL impairment than negatives, that is, difference of −8.50 points (95% CI −9.71 to −7.29; p<0.001) for EQVAS, which decreased by 1.49 points (95% CI 0.86 to 2.12; p<0.001) in individuals with PCC for each comorbidity present, and differences of −0.065 points (95% CI −0.074 to −0.056; p<0.001) for EQ5D index, and +16.72% (95% CI 15.01 to 18.43; p<0.001) for ADL impairment. Health and ADL impairment were similar in negatives and positives without PCC. Replacing the WHO case definition with other PCC definitions yielded comparable results. Conclusions Individuals with PCC have substantially worse health and more ADL impairment than negative controls, irrespective of the case definition. Authorities should inform the public about the associated burden of PCC and enable adequate support. Data are available upon reasonable request. Data cannot be shared publicly because the data contains potentially identifying patient information. Data are available on request from the head of the data-archiving South Limburg Public Health Service (contact via Helen.Sijstermans@ggdzl.nl) for researchers who meet the criteria for access to confidential data.

中文翻译：

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COVID-19 后状况对健康状况和日常生活活动的影响：PRIME 后 COVID 研究

目的 评估患有或不患有 COVID-19 后病症 (PCC) 的 SARS-CoV-2 阳性成年人的健康状况和日常生活活动 (ADL)，并将其与阴性测试个体进行比较。此外，将不同的 PCC 病例定义与 SARS-CoV-2 阴性个体进行了比较。方法 2020 年 6 月至 2021 年 11 月期间，所有在南林堡公共卫生服务中心（荷兰）检测出 SARS-CoV-2 PCR 呈阳性的成年人 (n=41 780) 与匹配的 PCR 阴性个体（年龄、性别、年份为 2:1） -季度测试，市政府；n=19 875）通过电子邮件邀请。评估健康（五级 EuroQol 五维（EQ5D）指数和 EuroQol 视觉模拟量表（EQVAS））和 ADL 损伤。 PCC 分类是使用 WHO 病例定义和其他五个常见定义进行的。结果 总共纳入了 8409 名个体（6381 名 SARS-CoV-2 阳性；53±15 岁；57% 女性；自测试后 9 (7-11) 个月）。根据 WHO 病例定义，39.4% 的阳性患者患有 PCC（EQVAS：71±20；EQ5D 指数：0.800±0.191；ADL 损伤：30 (10–70)%），并且被认为比阴性患者健康状况更差，ADL 损伤更多，即EQVAS 的差异为 -8.50 分（95% CI -9.71 至 -7.29；p<0.001），PCC 个体中存在的每种合并症降低了 1.49 分（95% CI 0.86 至 2.12；p<0.001），并且差异EQ5D 指数为 -0.065 分（95% CI -0.074 至 -0.056；p<0.001），ADL 损伤为 +16.72%（95% CI 15.01 至 18.43；p<0.001）。在没有 PCC 的情况下，健康和 ADL 损害在阴性和阳性方面相似。用其他 PCC 定义替换 WHO 病例定义产生了类似的结果。结论 无论病例定义如何，与阴性对照相比，PCC 患者的健康状况要差得多，ADL 损伤也更严重。当局应告知公众 PCC 的相关负担并提供足够的支持。数据可根据合理要求提供。数据无法公开共享，因为数据包含潜在的患者身份信息。符合访问机密数据标准的研究人员可根据南林堡公共卫生服务数据存档负责人的要求（通过 Helen.Sijstermans@ggdzl.nl 联系）获取数据。