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Palladium-catalyzed conversion of phenols into tetrahydroacridines
Green Chemistry ( IF 9.8 ) Pub Date : 2024-03-18 , DOI: 10.1039/d3gc05210a
Jianjin Yu 1 , Renqin Zhan 1 , Chao-Jun Li 2 , Huiying Zeng 1
Affiliation  

Phenols are readily available through the degradation of lignin, a naturally abundant and renewable resource. The acridine skeleton, commonly found in drug molecules, holds significant medicinal and synthetic value. Herein, we present a synthesis of tetrahydroacridines through the use of palladium as a catalyst, employing 2-aminoarylketones and phenols as key starting materials.

中文翻译:

钯催化酚类转化为四氢吖啶

酚类很容易通过木质素的降解获得,木质素是一种天然丰富的可再生资源。吖啶骨架常见于药物分子中,具有重要的药用和合成价值。在此,我们提出了一种通过使用钯作为催化剂、使用 2-氨基芳基酮和酚作为关键起始原料合成四氢吖啶的方法。
更新日期:2024-03-18
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