Oral diseases include oral cancer, periodontitis, endodontium infection, and caries. The oral cavity is prone to the proliferation of pathogenic bacteria and infectious diseases owing to its unique environment. During the drug-based treatment of oral diseases, saliva can dilute the drug formulation, reduce the interaction between the drug and site of action, and weaken drug efficacy. Therefore, searching an effective drug delivery approach is extremely critical and urgent. Stimuli responsive hydrogels respond to altered environmental conditions under disease states, allowing specific drug delivery. Accordingly, smart drug delivery systems can prolong the duration of drug action, reduce adverse reactions, decrease the frequency of administration, and improve patient compliance, thereby accelerating recovery. In this review, we discuss the different types of stimuli responsive hydrogels for smart drug delivery, focusing on their application in oral disease management. Further, we present current challenges and provide suggestions for future research on stimuli responsive hydrogels for oral disease treatment.

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用于口腔疾病治疗的刺激响应水凝胶的最新进展

口腔疾病包括口腔癌、牙周炎、牙髓感染和龋齿。口腔由于其独特的环境，很容易滋生病原菌，引发传染病。在口腔疾病药物治疗过程中，唾液会稀释药物制剂，减少药物与作用部位的相互作用，减弱药物疗效。因此，寻找有效的药物递送方法显得尤为关键和紧迫。刺激响应水凝胶可对疾病状态下改变的环境条件做出反应，从而实现特定的药物输送。因此，智能给药系统可以延长药物作用持续时间，减少不良反应，减少给药频率，提高患者依从性，从而加速康复。在这篇综述中，我们讨论了用于智能药物输送的不同类型的刺激响应水凝胶，重点关注它们在口腔疾病管理中的应用。此外，我们提出了当前的挑战，并为用于口腔疾病治疗的刺激响应水凝胶的未来研究提供了建议。