Arrest of bleeding usually applies clotting agents to trigger coagulation procedures or adhesives to interrupt blood flow through sealing the vessel; however, the efficiency is compromised. Here, we propose a concept of integration of hemostasis and adhesion via yam mucus's microgels. The mucus microgels exhibit attractive attributes of hydrogel with uniform size and shape. Their shear-thinning, self-healing and strong adhesion make them feasible as injectable bioadhesion. Exceptionally, the blood can trigger the microgels' gelation with the outcome of super extensibility, which leads to the microgels a strong hemostatic agent. We also found a tight gel adhesive layer formed upon microgels' contacting the blood on the tissue, where there is the coagulation factor XIII triggered to form a dense three-dimensional fibrin meshwork. The generated structures show that the microgels look like hard balls in the dispersed phase into the blood-produced fibrin mesh of a soft net phase. Both phases work together for a super-extension gel. We demonstrated the microgels' fast adhesion and hemostasis in the livers and hearts of rabbits and mini pigs. The microgels also promoted wound healing with good biocompatibility and biodegradability.

中文翻译：

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植物粘液微凝胶：血液引发的凝胶化和强止血粘附

止血通常使用凝血剂来触发凝血程序或使用粘合剂通过密封血管来中断血流；然而，效率受到影响。在这里，我们提出了通过山药粘液微凝胶整合止血和粘附的概念。粘液微凝胶具有水凝胶的吸引力，具有均匀的尺寸和形状。它们的剪切稀化、自修复和强粘附力使它们可以作为可注射的生物粘附剂。特别是，血液可以引发微凝胶的凝胶化，从而产生超强的延展性，这使得微凝胶成为一种强止血剂。我们还发现微凝胶与组织上的血液接触后形成紧密的凝胶粘合层，其中触发凝血因子XIII形成致密的三维纤维蛋白网。生成的结构表明，微凝胶看起来像分散相中的硬球，进入软网相的血液产生的纤维蛋白网中。两个相共同作用形成超延伸凝胶。我们证明了微凝胶在兔子和小型猪的肝脏和心脏中的快速粘附和止血作用。微凝胶还具有良好的生物相容性和生物降解性，可促进伤口愈合。