Crack is found on the soil when severe drought comes, which inspires the idea to rationalize patterning applications using dried deoxyribonucleic acid (DNA) film. DNA is one of the massively produced biomaterials in nature, showing the lyotropic liquid crystal (LC) phase in highly concentrated conditions. DNA nanostructures in the hydrated condition can be orientation controlled, which can be extended to make dryinginduced cracks. The controlled crack generation in oriented DNA films by inducing mechanical fracture through organic solvent-induced dehydration (OSID) using tetrahydrofuran (THF) is explored. The corresponding simulations show a strong correlation between the long axis of DNA due to the shrinkage during the dehydration and in the direction of crack propagation. The cracks are controlled by simple brushing and a 3D printing method. This facile way of aligning cracks will be used in potential patterning applications.

中文翻译：

---

通过有机溶剂诱导脱水在 DNA 薄膜上按需形成裂纹

当严重干旱到来时，土壤会出现裂缝，这激发了利用干燥脱氧核糖核酸 (DNA) 薄膜合理化图案应用的想法。 DNA是自然界中大量生产的生物材料之一，在高度浓缩的条件下呈现出溶致液晶（LC）相。 DNA纳米结构在水合状态下可以进行取向控制，可以延伸以产生干燥引起的裂纹。探索了通过使用四氢呋喃 (THF) 的有机溶剂诱导脱水 (OSID) 诱导机械断裂来控制定向 DNA 薄膜中裂纹的产生。相应的模拟显示，由于脱水过程中的收缩而导致的 DNA 长轴与裂纹扩展方向之间存在很强的相关性。通过简单的刷涂和3D打印方法即可控制裂缝。这种对齐裂纹的简便方法将用于潜在的图案化应用。