A radical 1,4-aryl migration enabling a cross-electrophile coupling reaction toward remote transalkylation of N-benzyl alanine has been developed. In this strategy, with the occurrence of a radical-mediated Turce-Smiles rearrangement, key α-aminoalkyl radicals are generated. The as-formed α-aminoalkyl radical serves as a robust coupling partner for cross-electrophilic coupling with vinyl triflates, affording a series of olefin-tethered amino acid motifs.

中文翻译：

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自由基 1,4-芳基迁移使得镍催化的 β-溴氨基酸酯与三氟甲磺酸乙烯酯发生远程交叉亲电子偶联

已经开发出一种自由基 1,4-芳基迁移，能够实现N-苄基丙氨酸远程反烷基化的交叉亲电子偶联反应。在该策略中，随着自由基介导的 Turce-Smiles 重排的发生，产生了关键的 α-氨基烷基自由基。所形成的α-氨基烷基作为与三氟甲磺酸乙烯酯交叉亲电偶联的稳健偶联伙伴，提供一系列烯烃束缚的氨基酸基序。