Vascular endothelial cells (ECs), the inner layer of blood vessels, were previously considered to be a passive lining that facilitates cellular and molecular exchange. However, recent studies have revealed that ECs can respond to various stimuli and actively regulate vascular function and skin inflammation. Specific subtypes of ECs are known to have significant roles in a diverse range of physiological and pathological processes in the skin. This review suggests that EC dysfunction is both causal and consequential in the pathogenesis of psoriasis. Further investigations into dysregulated pathways in EC dysfunction may provide new insights for the treatment of psoriasis.

中文翻译：

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银屑病的内皮功能障碍：综合评价


血管内皮细胞（EC）是血管的内层，以前被认为是促进细胞和分子交换的被动内层。然而，最近的研究表明，ECs可以对各种刺激做出反应，并主动调节血管功能和皮肤炎症。已知 EC 的特定亚型在皮肤的多种生理和病理过程中具有重要作用。本综述表明，EC 功能障碍在银屑病的发病机制中既是因果关系，又是结果关系。对 EC 功能障碍失调途径的进一步研究可能为银屑病的治疗提供新的见解。