Vitiligo is a disfiguring depigmentation disorder characterized by loss of melanocytes. Although numerous studies have been conducted on the pathogenesis of vitiligo, the underlying mechanisms remain unclear. Although most studies have focused on melanocytes and keratinocytes, growing evidence suggests the involvement of dermal fibroblasts, residing deeper in the skin. This review aims to elucidate the role of fibroblasts in both the physiological regulation of skin pigmentation and their pathological contribution to depigmentation, with the goal of shedding light on the involvement of fibroblasts in vitiligo. The topics covered in this review include alterations in the secretome, premature senescence, autophagy dysfunction, abnormal extracellular matrix, autoimmunity, and metabolic changes.

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成纤维细胞在白癜风中的新兴作用：以前被低估的后起之秀

白癜风是一种以黑色素细胞损失为特征的毁容性色素脱失性疾病。尽管对白癜风的发病机制进行了大量研究，但其潜在机制仍不清楚。尽管大多数研究都集中在黑素细胞和角质形成细胞上，但越来越多的证据表明，存在于皮肤深处的真皮成纤维细胞也参与其中。本综述旨在阐明成纤维细胞在皮肤色素沉着的生理调节及其对色素脱失的病理学贡献中的作用，旨在阐明成纤维细胞在白癜风中的参与。本综述涵盖的主题包括分泌组的改变、过早衰老、自噬功能障碍、细胞外基质异常、自身免疫和代谢变化。