The chronologically ordered generation of distinct cell types is essential for the establishment of neuronal diversity and the formation of neuronal circuits. Recently, single-cell transcriptomic analyses of various areas of the developing vertebrate nervous system have provided evidence for the existence of a shared temporal patterning program that partitions neurons based on the timing of neurogenesis. In this review, I summarize the findings that lead to the proposal of this shared temporal program before focusing on the developing spinal cord to discuss how temporal patterning in general and this program specifically contributes to the ordered formation of neuronal circuits.

中文翻译：

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脊椎动物神经管发育的时间模式

不同细胞类型按时间顺序生成对于神经元多样性的建立和神经元回路的形成至关重要。最近，对发育中的脊椎动物神经系统各个区域的单细胞转录组分析为共享时间模式程序的存在提供了证据，该程序根据神经发生的时间来划分神经元。在这篇综述中，我总结了导致提出这种共享时间程序的研究结果，然后重点关注发育中的脊髓，讨论一般时间模式和该程序如何具体促进神经元回路的有序形成。