Angelman Syndrome (AS) is a rare genetic disorder characterised by hyperactivity, overexcitability, developmental delays, and lack of speech. This study used secondary data analysis to investigate sleep disturbances in children and adolescents (n = 212) who are enrolled in the Global Angelman Syndrome Registry. Participants were divided into two groups based on the presence or absence of sleep disturbance. The cut-off score of 40 on the Sleep Disturbance Scale for Children was used to indicate the presence or absence of sleep disturbances. Sleep disturbances and their association with co-occurring conditions were examined regarding challenging behaviour, language and communication, infancy history, gastrointestinal symptoms, and epilepsy. Multiple regression was then conducted to investigate possible predictors for sleep disturbances. Children and adolescents with AS, with and without sleep disturbances, differed considerably regarding anxiety. Sleep disturbances were significantly associated with an ability to use spoken words and computerised communication devices, and anxiety was a predictor of sleep disturbances. Future research is necessary to replicate this novel research, and to advance the clinical treatment of sleep disturbances in children and adolescents with AS.

中文翻译：

---

天使综合征儿童和青少年睡眠障碍的相关因素

安杰曼综合症 (AS) 是一种罕见的遗传性疾病，其特征是多动、过度兴奋、发育迟缓和缺乏言语。本研究使用二次数据分析来调查登记在全球天使综合症登记处的儿童和青少年 (n = 212) 的睡眠障碍。根据是否存在睡眠障碍将参与者分为两组。儿童睡眠障碍量表的分界线为 40 分，用于表明是否存在睡眠障碍。研究人员检查了睡眠障碍及其与并发疾病的关系，包括挑战性行为、语言和沟通、婴儿期病史、胃肠道症状和癫痫。然后进行多元回归来研究睡眠障碍的可能预测因素。患有 AS 的儿童和青少年，无论有没有睡眠障碍，在焦虑方面都有很大差异。睡眠障碍与使用口语和计算机通信设备的能力显着相关，而焦虑是睡眠障碍的预测因素。未来的研究有必要重复这项新颖的研究，并推进 AS 儿童和青少年睡眠障碍的临床治疗。