An unprecedented base-build-up strategy has been applied for the synthesis of carbocyclic pyrazolo[3,4-d]pyrimidine nucleoside analogues. The analogues were synthesized at the very last stage to provide swift access to a concise set of compounds. A methoxy-substituted analogue displayed low micromolar activity against Trypanosoma brucei and Trypanosoma rhodesiense.

中文翻译：

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碳环吡唑并[3,4-d]嘧啶核苷类似物的实用和发散合成

前所未有的碱基构建策略已应用于碳环吡唑并[3,4- d ]嘧啶核苷类似物的合成。类似物是在最后阶段合成的，以便快速获得一组简洁的化合物。甲氧基取代的类似物对布氏锥虫和罗得西亚锥虫表现出低微摩尔活性。