The liver is not oblivious to the passage of time, as ageing is a major risk factor for the development of acute and chronic liver diseases. Ageing produces alterations in all hepatic cells, affecting their phenotype and function and worsening the prognosis of liver disease. The ageing process also implies the accumulation of a cellular state characterized by a persistent proliferation arrest and a specific secretory phenotype named cellular senescence. Indeed, senescent cells have key roles in many physiological processes; however, their accumulation owing to ageing or pathological conditions contributes to the damage occurring in chronic diseases. The aim of this Review is to provide an updated description of the pathophysiological events in which hepatic senescent cells are involved and their role in liver disease progression. Finally, we discuss novel geroscience therapies that could be applied to prevent or improve liver diseases and age-mediated hepatic deregulations.

肝脏不会忽视时间的流逝，因为衰老是急性和慢性肝病发展的主要危险因素。衰老会导致所有肝细胞发生变化，影响其表型和功能，并使肝病的预后恶化。衰老过程还意味着以持续增殖停滞和称为细胞衰老的特定分泌表型为特征的细胞状态的积累。事实上，衰老细胞在许多生理过程中发挥着关键作用。然而，它们由于衰老或病理状况而积累，会导致慢性疾病造成损害。本综述的目的是提供肝衰老细胞参与的病理生理事件及其在肝病进展中的作用的最新描述。最后，我们讨论了可用于预防或改善肝脏疾病和年龄介导的肝脏失调的新型老年科学疗法。