Background and objective

Glucose-6-phosphate dehydrogenase deficiency (G6PDD) being highly prevalent in the Middle East, the primary objective was to estimate the incidence of neonatal jaundice among G6PD-deficient neonates and to explore its association with various risk factors.

Methods

This retrospective cohort study includes 7 years data of neonates diagnosed with G6PDD between 1st January 2015, and 30 September 2022, from Al Wakra Hospital, HMC Qatar.

Results

Among the 40,305 total births, 1013 had G6PDD with an incidence of 2.51%. Of all the G6PDD babies, 24.6% (249/1013) received phototherapy and three babies required exchange transfusion. Statistically significant associations were noted between the need for phototherapy and gestational age, gestational age groups, birth weight, and birth weight groups, but logistic regression analysis showed significant association for phototherapy only with the gestational age group.

Conclusion

Universal screening and proper follow-up is essential for G6PDD as it plays crucial role in neonatal jaundice.

中文翻译：

---

6-磷酸葡萄糖脱氢酶缺乏症与新生儿间接高胆红素血症：一项针对 40,305 名连续出生婴儿的回顾性队列研究

背景和目标

6-磷酸葡萄糖脱氢酶缺乏症 (G6PDD) 在中东地区非常普遍，主要目的是估计 G6PD 缺乏新生儿中新生儿黄疸的发生率，并探讨其与各种危险因素的关联。

方法

这项回顾性队列研究包括 2015 年 1 月 1 日至 2022 年 9 月 30 日期间卡塔尔 HMC Al Wakra 医院诊断患有 G6PDD 的新生儿的 7 年数据。

结果

40305名新生儿中，1013人患有G6PDD，发病率为2.51%。在所有 G6PDD 婴儿中，24.6% (249/1013) 接受了光疗，其中 3 名婴儿需要换血。光疗需求与胎龄、胎龄组、出生体重和出生体重组之间存在统计学显着相关性，但逻辑回归分析显示光疗仅与胎龄组显着相关。

结论

普遍筛查和适当的随访对于 G6PDD 至关重要，因为它在新生儿黄疸中发挥着至关重要的作用。