A new site-selective methodology for C–H nitration of 2H-indazoles has been accomplished at the C7 position using iron(III) nitrate. This strategy enables practical access to an array of 7-nitroindazoles with broad functional group tolerance in good yields. The synthesized products have been proven as valuable synthetic intermediates by demonstrating the synthetic utility. Mechanistic investigations indicate that the reaction goes through a radical pathway.

中文翻译：

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2H-吲唑的位点选择性直接硝化：轻松获得7-硝基吲唑

使用硝酸铁 ( III )在 C7 位置完成了2 H-吲唑 C-H 硝化的新位点选择方法。该策略能够以良好的产率实际获得一系列具有广泛官能团耐受性的 7-硝基吲唑。通过展示合成实用性，合成的产物已被证明是有价值的合成中间体。机理研究表明该反应经历了自由基途径。