Monitoring of isoprene in exhaled breath is expected to provide a noninvasive and painless method for dynamic monitoring of physiological and metabolic states during exercise. However, for real-time and portable detection of isoprene, gas sensors have become the best choice for gas detection technology, which are crucial to achieving the goal of anytime, anywhere, human-centered healthcare in the future. Here, we first report a mixed potential type isoprene sensor based on a Gd2Zr2O7 solid electrolyte and a CdSb2O6 sensing electrode, which enables sensitive detection for isoprene with sensitivities of −21.2 mV/ppm and −65.8 mV/decade in the range of 0.05–1 and 1–100 ppm. The sensing behavior of the sensor follows the mixed potential sensing mechanism and was further verified by the electrochemical polarization curves. The significant differentiation between the sensor response to exhaled breath of healthy individuals and simulated breath containing different concentrations of isoprene demonstrates the potential of the sensor for the detection of isoprene in exhaled breath. Simultaneously, monitoring of isoprene during exercise signifies the feasibility of the sensor in dynamic monitoring of physiological indicators, which is not only of great significance for optimizing training and guiding therapeutic exercise intervention in sporting scenarios but also expected to help further reveal the interaction between exercise, muscle, and organ metabolism in medicine.

中文翻译：

---

混合电位型异戊二烯传感器在生物标记气体实时监测中的应用

监测呼出气中的异戊二烯有望为动态监测运动过程中的生理和代谢状态提供一种无创、无痛的方法。然而，对于异戊二烯的实时、便携式检测，气体传感器已成为气体检测技术的最佳选择，这对于未来实现随时随地、以人为本的医疗保健目标至关重要。在这里，我们首次报道了一种基于 Gd2Zr2O7 固体电解质和 CdSb2O6 传感电极的混合电位型异戊二烯传感器，该传感器能够灵敏地检测异戊二烯，在 0.05-1 范围内灵敏度为 -21.2 mV/ppm 和 -65.8 mV/decade和 1–100 ppm。传感器的传感行为遵循混合电位传感机制，并通过电化学极化曲线进一步验证。传感器对健康个体呼出气的响应与含有不同浓度异戊二烯的模拟呼吸之间的显着差异证明了传感器用于检测呼出气中异戊二烯的潜力。同时，运动过程中异戊二烯的监测标志着该传感器动态监测生理指标的可行性，不仅对于优化训练、指导运动场景下的治疗性运动干预具有重要意义，也有望有助于进一步揭示运动、运动之间的相互作用。医学中的肌肉和器官代谢。