Interstitial fluid (ISF) has attracted extensive attention in an extremely wide range of areas due to its unique advantages, such as portability, high precision, comfortable operation, and superior stability. In recent years, the microneedle (MN) technique has been considered to be an excellent tool for extracting ISF because it is painless and noninvasive. Recent reports have shown that MN has good application prospects in ISF extraction. In this review, we provide comprehensive and in-depth insight into integrated MN devices for ISF detection, covering the basic structure as well as the fabrication of integrated MN devices and various applications in ISF extraction. Challenges and prospects are highlighted, with a discussion on how to transition such MN-integrated devices toward personalized healthcare monitoring systems.

中文翻译：

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皮肤 ISF 内基于微针的传感技术的最新进展综述，这可能会改变医学测试

间质液（ISF）以其便携、高精度、操作舒适、稳定性优越等独特优势，在极其广泛的领域受到广泛关注。近年来，微针（MN）技术因其无痛、无创而被认为是提取ISF的绝佳工具。最近的报道表明MN在ISF提取中具有良好的应用前景。在这篇综述中，我们对用于 ISF 检测的集成 MN 器件进行了全面、深入的了解，涵盖了集成 MN 器件的基本结构、制造以及 ISF 提取中的各种应用。强调了挑战和前景，并讨论了如何将此类 MN 集成设备过渡到个性化医疗保健监控系统。