INTRODUCTIONDepressive symptoms are associated with higher risk of dementia, but how they impact cognition in diverse populations is unclear.METHODSAsian, Black, Latino, or White participants (n = 2227) in the Kaiser Healthy Aging and Diverse Life Experiences (age 65+) and the Study of Healthy Aging in African Americans (age 50+) underwent up to three waves of cognitive assessments over 4 years. Multilevel models stratified by race/ethnicity were used to examine whether depressive symptoms were associated with cognition or cognitive decline and whether associations differed by race/ethnicity.RESULTSHigher depressive symptoms were associated with lower baseline verbal episodic memory scores (−0.06, 95% CI: −0.12, −0.01; −0.15, 95% CI: −0.25, −0.04), and faster decline annually in semantic memory (−0.04, 95% CI: −0.07, −0.01; −0.10, 95% CI: −0.15, −0.05) for Black and Latino participants. Depressive symptoms were associated with lower baseline but not decline in executive function.DISCUSSIONDepressive symptoms were associated with worse cognitive outcomes, with some evidence of heterogeneity across racial/ethnic groups.HIGHLIGHTS We examined whether baseline depressive symptoms were differentially associated with domain‐specific cognition or cognitive decline by race/ethnicity. Depressive symptoms were associated with worse cognitive scores for all racial/ethnic groups across different domains examined. Higher depressive symptoms were associated with faster cognitive decline for semantic memory for Black and Latino participants. The results suggest a particularly harmful association between depressive symptoms and cognition in certain racial/ethnic groups.

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老年人抑郁症状与认知结果之间关系的种族差异：KHANDLE 和 STAR 的研究结果

简介抑郁症状与较高的痴呆风险相关，但它们如何影响不同人群的认知尚不清楚。方法亚裔、黑人、拉丁裔或白人参与者（n= 2227）在凯撒健康老龄化和多样化生活经历（65 岁以上）和非裔美国人健康老龄化研究（50 岁以上）中进行了 4 年多的三轮认知评估。按种族/民族分层的多水平模型用于检查抑郁症状是否与认知或认知能力下降相关，以及这种关联是否因种族/民族而异。 结果较高的抑郁症状与较低的基线言语情景记忆得分相关（−0.06，95% CI： -0.12，-0.01；-0.15，95% CI：-0.25，-0.04），并且语义记忆每年下降速度更快（-0.04，95% CI：-0.07，-0.01；-0.10，95% CI：-0.15 ，-0.05）对于黑人和拉丁裔参与者。抑郁症状与较低的基线相关，但与执行功能下降无关。讨论抑郁症状与较差的认知结果相关，有一些证据表明不同种族/族裔群体之间存在异质性。 我们检查了基线抑郁症状是否与种族/民族的特定领域认知或认知下降存在差异相关。 对于所检查的不同领域的所有种族/族裔群体来说，抑郁症状与较差的认知得分相关。 黑人和拉丁裔参与者的抑郁症状越高，语义记忆的认知能力下降越快。 结果表明，某些种族/族裔群体的抑郁症状与认知之间存在特别有害的关联。