Even though subconjunctival injections are used in clinics, their quantitative pharmacokinetics has not been studied systematically. For this purpose, we evaluated the ocular and plasma pharmacokinetics of subconjunctival dexamethasone in rabbits. Intravenous injection was also given to enable a better understanding of the systemic pharmacokinetics. Dexamethasone concentrations in plasma (after subconjunctival and intravenous injections) and four ocular tissues (iris-ciliary body, aqueous humour, neural retina and vitreous) were analysed using LC-MS/MS.

中文翻译：

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地塞米松在兔结膜下和静脉注射后的综合眼部和全身药代动力学

尽管结膜下注射已用于临床，但其定量药代动力学尚未得到系统研究。为此，我们评估了兔结膜下地塞米松的眼部和血浆药代动力学。还进行了静脉注射，以便更好地了解全身药代动力学。使用 LC-MS/MS 分析血浆（结膜下和静脉注射后）和四种眼组织（虹膜睫状体、房水、神经视网膜和玻璃体）中的地塞米松浓度。