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Phototoxicity in vitro and safety in vivo of the emulsion photosensitizer based on furanocoumarins of Heracleum sosnowskyi
European Journal of Pharmaceutics and Biopharmaceutics ( IF 4.9 ) Pub Date : 2024-03-12 , DOI: 10.1016/j.ejpb.2024.114257
Oleg A. Kulikov , Vasilisa I. Shlyapkina , Ekaterina P. Brodovskaya , Amina M. Al-khadj Aioub , Valentin P. Ageev , Mikhail N. Zharkov , Denis E. Yakobson , Daniil S. Sokushev , Nikolay A. Pyataev , Gleb B. Sukhorukov

The use of plants such as giant hogweed as raw materials for the manufacture of dosage forms has been little explored. In this study, we utilized furanocoumarins from the plant to create an experimental emulsion dosage form (EmFHS). The EmFHS was finely dispersed (481.8 nm ± 71.1 nm), shelf-stable, and contained predominantly 8-methoxypsoralen at a concentration of 1 mg/ml.

中文翻译:

索斯诺斯基呋喃香豆素乳液光敏剂的体外光毒性和体内安全性

使用大猪草等植物作为制造剂型的原材料的探索很少。在这项研究中,我们利用植物中的呋喃香豆素创建了一种实验性乳剂剂型 (EmFHS)。 EmFHS 精细分散 (481.8 nm ± 71.1 nm),储存稳定,主要含有浓度为 1 mg/ml 的 8-甲氧基补骨脂素。
更新日期:2024-03-12
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