Human-centric methodologies like microphysiological systems and methods have shown promise in addressing the limitations of animal models in understanding human biology and responding to public health priorities. However, the prevailing paradigm based on animal research persists. The article proposes a systemic thinking approach, endorsed by the OECD and the EU, as a tool to leverage innovation to reframe the issue and achieve transformative policies. By identifying the complex factors shaping method selection in basic and biomedical research, a simplified model is presented to illuminate the systemic nature of this decision-making process. The goal is not to prescribe solutions but to offer policymakers a new framework for more-effective strategies, emphasizing collaboration among stakeholders and the need for robust data.

中文翻译：

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将生物医学研究转向以人为中心的方法：基于系统的策略

以人类为中心的方法论，如微生理系统和方法，在解决动物模型在理解人类生物学和应对公共卫生优先事项方面的局限性方面显示出了希望。然而，基于动物研究的流行范式仍然存在。本文提出了一种得到经合组织和欧盟认可的系统思维方法，作为利用创新来重新定义问题并实现变革性政策的工具。通过识别基础和生物医学研究中影响方法选择的复杂因素，提出了一个简化的模型来阐明这一决策过程的系统性。其目标不是制定解决方案，而是为政策制定者提供一个新的框架，以制定更有效的战略，强调利益相关者之间的合作以及对可靠数据的需求。