Given the challenge of multidrug resistance in antibiotics, non-antibiotic–dependent antibacterial strategies show promise for anti-infective therapy. V₂C MXene-based nanomaterials have demonstrated strong biocompatibility and photothermal conversion efficiency (PCE) for photothermal therapy (PTT). However, the limitation of V₂C MXene's laser irradiation to the near-infrared region I (NIR-I) restricts tissue penetration, making it difficult to achieve complete bacterial eradication with single-effect therapeutic strategies. To address this, Pt nanoparticles (Pt NPs) are attached to V₂C, forming artificial nanoplatforms (Pt@V₂C). Pt@V₂C exhibits enhanced PCE (59.6%) and a longer irradiation laser (NIR-II) due to the surface plasmon resonance effect of Pt NPs and V₂C. Notably, Pt@V₂C displays dual enzyme-like activity with chemodynamic therapy (CDT) and NIR-II enhanced dual enzyme-like activity. The biocatalytic mechanism of Pt@V₂C is elucidated using density functional theory. In an in vivo animal model, Pt@V₂C effectively eliminates methicillin-resistant Staphylococcus aureus from deep-seated tissues in subcutaneous abscesses and bacterial keratitis environments, accelerating abscess resolution and promoting wound and cornea healing through the synergistic effects of PTT/CDT. Transcriptomic analysis reveals that Pt@V₂C targets inflammatory pathways, providing insight into its therapeutic mechanism. This study presents a promising therapeutic approach involving hyperthermia-amplified biocatalysis with Pt NPs and MXene nanocomposites.

中文翻译：

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具有 NIR-II 增强纳米酶效应的铂纳米颗粒调节 V2C MXene 纳米平台，用于光热和化学动力学抗感染治疗

鉴于抗生素多重耐药性的挑战，非抗生素依赖性抗菌策略显示出抗感染治疗的希望。基于V ₂ C MXene的纳米材料在光热治疗（PTT）中表现出强大的生物相容性和光热转换效率（PCE）。_{然而，V 2} C MXene的激光照射仅限于近红外区I（NIR-I），限制了组织穿透，使得单效治疗策略难以实现完全根除细菌。为了解决这个问题，Pt 纳米颗粒 (Pt NP) 附着在 V ₂ C 上，形成人造纳米平台 (Pt@V ₂ C)。由于 Pt NP 和 V 2 _{C的表面等离子共振效应，Pt@V 2} C 表现出增强的 PCE (59.6%) 和更长的照射激光 (NIR-II) 。值得注意的是，Pt@V ₂ C 表现出双重酶样活性化学动力学疗法 (CDT) 和 NIR-II 增强了双酶样活性。利用密度泛函理论阐明了Pt@V ₂ C的生物催化机制。在体内动物模型中，Pt@V ₂ C可有效消除皮下脓肿和细菌性角膜炎环境中深层组织中的耐甲氧西林金黄色葡萄球菌，通过PTT/CDT的协同作用加速脓肿消退并促进伤口和角膜愈合。转录组分析表明，Pt@V ₂ C 靶向炎症途径，从而深入了解其治疗机制。这项研究提出了一种有前途的治疗方法，涉及 Pt NP 和 MXene 纳米复合材料的热放大生物催化。