In the face of the serious threat to human health and the economic burden caused by bacterial antibiotic resistance, 2D phosphorus nanomaterials have been widely used as antibacterial agents. Violet phosphorus nanosheets (VPNSs) are an exciting bandgap-adjustable 2D nanomaterial due to their good physicochemical properties, yet the study of VPNS-based antibiotics is still in its infancy. Here, a composite of gold nanorods (AuNRs) loaded onto VPNS platforms (VPNS/AuNR) is constructed to maximize the potential of VPNSs for antimicrobial applications. The loading with AuNRs not only enhances the photothermal performance via a localized surface plasmon resonance (LSPR) effect, but also enhances the light absorption capacity due to the narrowing of the band gap of the VPNSs, thus increasing the ROS generation capacity. The results demonstrate that VPNS/AuNR exhibits outstanding antibacterial properties and good biocompatibility. Attractively, VPNS/AuNR is then extensively tested for treating skin wound infections, suggesting promising in vivo antibacterial and wound-healing features. Our findings may open a novel direction to develop a versatile VPNS-based treatment platform, which can significantly boost the progress of VPNS exploration.

中文翻译：

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通过在紫光磷烯纳米片上负载金纳米棒来调节带隙和局域表面等离子体共振，用于光动力/光热协同抗感染治疗

面对细菌抗生素耐药性对人类健康的严重威胁和造成的经济负担，二维磷纳米材料作为抗菌剂得到了广泛的应用。紫磷纳米片（VPNS）因其良好的理化性质而成为一种令人兴奋的带隙可调二维纳米材料，但基于 VPNS 的抗生素的研究仍处于起步阶段。在此，构建了加载到 VPNS 平台 (VPNS/AuNR) 上的金纳米棒 (AuNR) 复合材料，以最大限度地发挥 VPNS 抗菌应用的潜力。 AuNRs的负载不仅通过局域表面等离子体共振（LSPR）效应增强了光热性能，而且由于VPNSs带隙变窄而增强了光吸收能力，从而增加了ROS的产生能力。结果表明VPNS/AuNR表现出优异的抗菌性能和良好的生物相容性。有吸引力的是，VPNS/AuNR 随后被广泛测试用于治疗皮肤伤口感染，表明其具有良好的体内抗菌和伤口愈合功能。我们的研究结果可能为开发基于 VPNS 的多功能治疗平台开辟新的方向，这可以显着推动 VPNS 探索的进展。