Lifetime Stressful Events Associated with Alzheimer's Pathologies, Neuroinflammation and Brain Structure in a Risk Enriched Cohort,Annals of Neurology

当前位置： X-MOL 学术 › Ann. Neurol. › 论文详情

Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)

Lifetime Stressful Events Associated with Alzheimer's Pathologies, Neuroinflammation and Brain Structure in a Risk Enriched Cohort
Annals of Neurology ( IF 11.2 ) Pub Date : 2024-03-11 , DOI: 10.1002/ana.26881
Eleni Palpatzis _{1,

2,

3} , Muge Akinci _{1,

2,

3} , Pablo Aguilar‐Dominguez _{1,

2} , Marina Garcia‐Prat ₃ , Kaj Blennow _{4,

5} , Henrik Zetterberg _{4,

5,

6,

7,

8} , Margherita Carboni ₉ , Gwendlyn Kollmorgen ₁₀ , Norbert Wild ₁₀ , Karine Fauria _{3,

11,

12} , Carles Falcon _{3,

11,

12} , Juan Domingo Gispert _{3,

11,

13} , Marc Suárez‐Calvet _{3,

11,

13,

14} , Oriol Grau‐Rivera _{3,

11,

13,

14} , Gonzalo Sánchez‐Benavides _{3,

11,

13} , Eider M. Arenaza‐Urquijo _{1,

3,

11,

13} ,

Affiliation

Barcelona Institute for Global Health (ISGlobal) Barcelona Spain
University of Pompeu Fabra (UPF) Barcelona Spain
Barcelonaβeta Brain Research Center (BBRC) Pasqual Maragall Foundation Barcelona Spain
Department of Psychiatry and Neurochemistry Institute of Neuroscience and Physiology, University of Gothenburg Mölndal Sweden
Clinical Neurochemistry Laboratory Sahlgrenska University Hospital Mölndal Sweden
UK Dementia Research Institute at UCL London United Kingdom
Department of Neurodegenerative Disease UCL Institute of Neurology London United Kingdom
Hong Kong Center for Neurodegenerative Diseases, Clear Water Bay Hong Kong China
Roche Diagnostics International Ltd Rotkreuz Switzerland
Roche Diagnostics GmbH Penzberg Germany
IMIM (Hospital del Mar Medical Research Institute) Barcelona Spain
Centro de Investigación Biomédica en Red Bioingeniería Biomateriales y Nanomedicina, Instituto de Salud Carlos III Madrid Spain
Centro de Investigación Biomédica en Red de Fragilidad y Envejecimiento Saludable (CIBERFES) Madrid Spain
Servei de Neurologia Hospital del Mar Barcelona Spain

Along with the known effects of stress on brain structure and inflammatory processes, increasing evidence suggest a role of chronic stress in the pathogenesis of Alzheimer's disease (AD). We investigated the association of accumulated stressful life events (SLEs) with AD pathologies, neuroinflammation, and gray matter (GM) volume among cognitively unimpaired (CU) individuals at heightened risk of AD.

中文翻译：

与阿尔茨海默病病理学、神经炎症和高风险人群大脑结构相关的终生压力事件

除了已知的压力对大脑结构和炎症过程的影响外，越来越多的证据表明慢性压力在阿尔茨海默病 (AD) 的发病机制中发挥着作用。我们研究了 AD 风险较高的认知未受损 (CU) 个体中累积的压力生活事件 (SLE) 与 AD 病理、神经炎症和灰质 (GM) 体积的关系。

更新日期：2024-03-11

点击分享查看原文

点击收藏

公开下载

阅读更多本刊最新论文本刊介绍/投稿指南

全部期刊列表>>