In cystic fibrosis (CF), infection plays a critical role in disease progression. Although multiple studies suggest that airway commensals might be able to interfere with pathogenic bacteria, the role of the distinct commensals in the polymicrobial lung infections is largely unknown. In this study, we aimed to identify airway commensal bacteria that may inhibit the growth of . Through a screening study with more than 80 CF commensal strains across 21 species, more than 30 commensal strains from various species have been identified to be able to inhibit the growth of . The underlying mechanisms were investigated via genomic, metabolic and functional analysis, revealing that the inhibitory commensals may affect the growth of by releasing a large amount of acetic acid. The data provide information about the distinct roles of airway commensals and provide insights into novel strategies for controlling airway infections.

中文翻译：

---

囊性纤维化中的气道共生细菌通过释放的代谢物抑制铜绿假单胞菌的生长

在囊性纤维化（CF）中，感染在疾病进展中起着至关重要的作用。尽管多项研究表明气道共生菌可能能够干扰病原菌，但不同共生菌在多种微生物肺部感染中的作用在很大程度上尚不清楚。在这项研究中，我们的目的是鉴定可能抑制 生长的气道共生细菌。通过对21个物种的80多个CF共生菌株的筛选研究，已鉴定出来自不同物种的30多个共生菌株能够抑制.通过基因组、代谢和功能分析研究了其潜在机制，揭示了抑制共生体可能通过释放大量乙酸来影响生长。这些数据提供了有关气道共生菌不同作用的信息，并为控制气道感染的新策略提供了见解。